Server Error in ‘/xxxx/ Application.

Failed to access IIS metabase.

Description: An unhandled exception occurred during the execution of the current web request. Please review the stack trace for more information about the error and where it originated in the code.

Exception Details: System.Web.Hosting.HostingEnvironmentException: Failed to access IIS metabase.

The process account used to run ASP.NET must have read access to the IIS metabase (e.g. IIS://servername/W3SVC). For information on modifying metabase permissions, please see http://support.microsoft.com/?kbid=267904.

Source Error:

An unhandled exception was generated during the execution of the current web request. Information regarding the origin and location of the exception can be identified using the exception stack trace below.

Stack Trace:

[HostingEnvironmentException: Failed to access IIS metabase.] System.Web.Configuration.MetabaseServerConfig.MapPathCaching(String siteID, VirtualPath path) +3492170 System.Web.Configuration.MetabaseServerConfig.System.Web.Configuration.IConfigMapPath.MapPath(String siteID, VirtualPath vpath) +9 System.Web.Hosting.HostingEnvironment.MapPathActual(VirtualPath virtualPath, Boolean permitNull) +163 System.Web.CachedPathData.GetConfigPathData(String configPath) +382 System.Web.CachedPathData.GetConfigPathData(String configPath) +243 System.Web.CachedPathData.GetApplicationPathData() +68 System.Web.CachedPathData.GetVirtualPathData(VirtualPath virtualPath, Boolean permitPathsOutsideApp) +3385679 System.Web.Configuration.RuntimeConfig.GetLKGRuntimeConfig(VirtualPath path) +189
Version Information: Microsoft .NET Framework Version:2.0.50727.42; ASP.NET Version:2.0.50727.42

Solución:

Error dado en IIS 5.00 en Windows xp SP2. Solucionado con %systemroot%\Microsoft.NET\Framework\v1.1.4322\aspnet_regiis.exe /i
y luego con %systemroot%\Microsoft.NET\Framework\v2.0.50727>aspnet_regiis.exe -ga ASPNET

El primer comando lo que hace es regenerar el usuario con el que se ejecuta el proceso de ASP.NET en caso de que este corrupto. El segundo comando, permite que ese usuario(user ASPNET) tenga acceso a la metabase del IIS.